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2pjt

From Proteopedia

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{{STRUCTURE_2pjt| PDB=2pjt | SCENE= }}
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'''Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344'''
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===Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344===
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==Overview==
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A series of beta-sulfonyl hydroxamate TACE inhibitors, bearing a butynylamino or a butynyloxy P1' group, was designed and synthesized. Of the compounds investigated, 22 has excellent potency against isolated TACE enzyme, shows good selectivity over MMP-2 and MMP-13, and oral activity in an in vivo mouse model of TNF-alpha production.
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(as it appears on PubMed at http://www.pubmed.gov), where 17606376 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17606376}}
==About this Structure==
==About this Structure==
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[[Category: Zinc chelator]]
[[Category: Zinc chelator]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:39:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:25:18 2008''

Revision as of 01:25, 28 July 2008

Image:2pjt.png

Template:STRUCTURE 2pjt

Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344

Template:ABSTRACT PUBMED 17606376

About this Structure

2PJT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket., Huang A, Joseph-McCarthy D, Lovering F, Sun L, Wang W, Xu W, Zhu Y, Cui J, Zhang Y, Levin JI, Bioorg Med Chem. 2007 Sep 15;15(18):6170-81. Epub 2007 Jun 20. PMID:17606376

Page seeded by OCA on Mon Jul 28 04:25:18 2008

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