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1u0r

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[[Image:1u0r.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1u0r| PDB=1u0r | SCENE= }}
{{STRUCTURE_1u0r| PDB=1u0r | SCENE= }}
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'''Crystal structure of Mycobacterium tuberculosis NAD kinase'''
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===Crystal structure of Mycobacterium tuberculosis NAD kinase===
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==Overview==
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NAD kinase catalyzes the magnesium-dependent phosphorylation of NAD, representing the sole source of freshly synthesized NADP in all organisms. The enzyme is essential for the growth of the deadly multidrug-resistant pathogen Mycobacterium tuberculosis and is an attractive target for novel antitubercular agents. The crystal structure of NAD kinase has been solved by multiwavelength anomalous dispersion at a resolution of 2.3 A in its T state. Two crystal forms have been obtained revealing either a dimer or a tetramer. The enzyme architecture discloses a novel molecular arrangement, with each subunit consisting of an alpha/beta N-terminal domain and a C-terminal 12-stranded beta sandwich domain, connected by swapped beta strands. The C-terminal domain shows a striking internal approximate 222 symmetry and an unprecedented topology, revealing a novel fold within the family of all beta structures. The catalytic site is located in the long crevice that defines the interface between the domains. The conserved GGDG structural fingerprint of the catalytic site is reminiscent of the related region in 6-phosphofructokinase, supporting the hypothesis that NAD kinase belongs to a newly reported superfamily of kinases.
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(as it appears on PubMed at http://www.pubmed.gov), where 15269221 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15269221}}
==About this Structure==
==About this Structure==
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[[Category: Tb structural genomics consortium]]
[[Category: Tb structural genomics consortium]]
[[Category: Tbsgc]]
[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:36:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:38:39 2008''

Revision as of 01:38, 28 July 2008

Image:1u0r.png

Template:STRUCTURE 1u0r

Crystal structure of Mycobacterium tuberculosis NAD kinase

Template:ABSTRACT PUBMED 15269221

About this Structure

1U0R is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis., Garavaglia S, Raffaelli N, Finaurini L, Magni G, Rizzi M, J Biol Chem. 2004 Sep 24;279(39):40980-6. Epub 2004 Jul 21. PMID:15269221

Page seeded by OCA on Mon Jul 28 04:38:39 2008

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