This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1xq8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1xq8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1xq8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1xq8| PDB=1xq8 | SCENE= }}
{{STRUCTURE_1xq8| PDB=1xq8 | SCENE= }}
-
'''Human micelle-bound alpha-synuclein'''
+
===Human micelle-bound alpha-synuclein===
-
==Overview==
+
<!--
-
Misfolding of the protein alpha-synuclein (aS), which associates with presynaptic vesicles, has been implicated in the molecular chain of events leading to Parkinson's disease. Here, the structure and dynamics of micelle-bound aS are reported. Val3-Val37 and Lys45-Thr92 form curved alpha-helices, connected by a well ordered, extended linker in an unexpected anti-parallel arrangement, followed by another short extended region (Gly93-Lys97), overlapping the recently identified chaperone-mediated autophagy recognition motif and a highly mobile tail (Asp98-Ala140). Helix curvature is significantly less than predicted based on the native micelle shape, indicating a deformation of the micelle by aS. Structural and dynamic parameters show a reduced helical content for Ala30-Val37. A dynamic variation in interhelical distance on the microsecond timescale is complemented by enhanced sub-nanosecond timescale dynamics, particularly in the remarkably glycine-rich segments of the helices. These unusually rich dynamics may serve to mitigate the effect of aS binding on membrane fluidity. The well ordered conformation of the helix-helix connector indicates a defined interaction with lipidic surfaces, suggesting that, when bound to larger diameter synaptic vesicles, it can act as a switch between this structure and a previously proposed uninterrupted helix.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15615727}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15615727 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15615727}}
==About this Structure==
==About this Structure==
-
1XQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQ8 OCA].
+
1XQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQ8 OCA].
==Reference==
==Reference==
Line 27: Line 31:
[[Category: Ulmer, T S.]]
[[Category: Ulmer, T S.]]
[[Category: Micelle-bound helix]]
[[Category: Micelle-bound helix]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:21:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:45:05 2008''

Revision as of 01:45, 28 July 2008

Image:1xq8.png

Template:STRUCTURE 1xq8

Human micelle-bound alpha-synuclein

Template:ABSTRACT PUBMED 15615727

About this Structure

1XQ8 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and dynamics of micelle-bound human alpha-synuclein., Ulmer TS, Bax A, Cole NB, Nussbaum RL, J Biol Chem. 2005 Mar 11;280(10):9595-603. Epub 2004 Dec 22. PMID:15615727

Page seeded by OCA on Mon Jul 28 04:45:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xq8"
Personal tools