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1yed

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[[Image:1yed.gif|left|200px]]
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{{Seed}}
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[[Image:1yed.png|left|200px]]
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{{STRUCTURE_1yed| PDB=1yed | SCENE= }}
{{STRUCTURE_1yed| PDB=1yed | SCENE= }}
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'''STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4)'''
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===STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4)===
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==Overview==
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The x-ray structures of three esterase-like catalytic antibodies identified by screening for catalytic activity the entire hybridoma repertoire, elicited in response to a phosphonate transition state analog (TSA) hapten, were analyzed. The high resolution structures account for catalysis by transition state stabilization, and in all three antibodies a tyrosine residue participates in the oxyanion hole. Despite significant conformational differences in their combining sites, the three antibodies, which are the most efficient among those elicited, achieve catalysis in essentially the same mode, suggesting that evolution for binding to a single TSA followed by screening for catalysis lead to antibodies with structural convergence.
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(as it appears on PubMed at http://www.pubmed.gov), where 9027317 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9027317}}
==About this Structure==
==About this Structure==
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[[Category: Catalytic antibody]]
[[Category: Catalytic antibody]]
[[Category: Transition state analogue]]
[[Category: Transition state analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:13:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:45:24 2008''

Revision as of 01:45, 28 July 2008

Image:1yed.png

Template:STRUCTURE 1yed

STRUCTURE OF A CATALYTIC ANTIBODY IGG2A FAB FRAGMENT (D2.4)

Template:ABSTRACT PUBMED 9027317

About this Structure

1YED is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural convergence in the active sites of a family of catalytic antibodies., Charbonnier JB, Golinelli-Pimpaneau B, Gigant B, Tawfik DS, Chap R, Schindler DG, Kim SH, Green BS, Eshhar Z, Knossow M, Science. 1997 Feb 21;275(5303):1140-2. PMID:9027317

Page seeded by OCA on Mon Jul 28 04:45:24 2008

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