This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1yp8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1yp8.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1yp8.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1yp8| PDB=1yp8 | SCENE= }}
{{STRUCTURE_1yp8| PDB=1yp8 | SCENE= }}
-
'''Solution structure of the cyclotide tricyclon A'''
+
===Solution structure of the cyclotide tricyclon A===
-
==Overview==
+
<!--
-
Cyclotides are a family of plant proteins that have the unusual combination of head-to-tail backbone cyclization and a cystine knot motif. They are exceptionally stable and show resistance to most chemical, physical, and enzymatic treatments. The structure of tricyclon A, a previously unreported cyclotide, is described here. In this structure, a loop that is disordered in other cyclotides forms a beta sheet that protrudes from the globular core. This study indicates that the cyclotide fold is amenable to the introduction of a range of structural elements without affecting the cystine knot core of the protein, which is essential for the stability of the cyclotides. Tricyclon A does not possess a hydrophobic patch, typical of other cyclotides, and has minimal hemolytic activity, making it suitable for pharmaceutical applications. The 22 kDa precursor protein of tricyclon A was identified and provides clues to the processing of these fascinating miniproteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15893660}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15893660 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15893660}}
==About this Structure==
==About this Structure==
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP8 OCA].
+
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YP8 OCA].
==Reference==
==Reference==
Line 27: Line 31:
[[Category: Cyclotide]]
[[Category: Cyclotide]]
[[Category: Cystine knot]]
[[Category: Cystine knot]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:36:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:03:45 2008''

Revision as of 02:03, 28 July 2008

Image:1yp8.png

Template:STRUCTURE 1yp8

Solution structure of the cyclotide tricyclon A

Template:ABSTRACT PUBMED 15893660

About this Structure

Full experimental information is available from OCA.

Reference

Processing of a 22 kDa precursor protein to produce the circular protein tricyclon A., Mulvenna JP, Sando L, Craik DJ, Structure. 2005 May;13(5):691-701. PMID:15893660

Page seeded by OCA on Mon Jul 28 05:03:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yp8"
Personal tools