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1lep

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{{STRUCTURE_1lep| PDB=1lep | SCENE= }}
{{STRUCTURE_1lep| PDB=1lep | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF THE IMMUNODOMINANT HEAT-SHOCK PROTEIN CHAPERONIN-10 OF MYCOBACTERIUM LEPRAE'''
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===THREE-DIMENSIONAL STRUCTURE OF THE IMMUNODOMINANT HEAT-SHOCK PROTEIN CHAPERONIN-10 OF MYCOBACTERIUM LEPRAE===
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==Overview==
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Members of the chaperonin-10 (cpn10) protein family, also called heat shock protein 10 and in Escherichia coli GroES, play an important role in ensuring the proper folding of many proteins. The crystal structure of the Mycobacterium leprae cpn10 (Ml-cpn10) oligomer has been elucidated at a resolution of 3.5 angstroms. The architecture of the Ml-cpn10 heptamer resembles a dome with an oculus in its roof. The inner surface of the dome is hydrophilic and highly charged. A flexible region, known to interact with cpn60, extends from the lower rim of the dome. With the structure of a cpn10 heptamer now revealed and the structure of the E. coli GroEL previously known, models of cpn10:cpn60 and GroEL:GroES complexes are proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 8539620 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8539620}}
==About this Structure==
==About this Structure==
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[[Category: Chaperone]]
[[Category: Chaperone]]
[[Category: Heat shock]]
[[Category: Heat shock]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:51:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:22:06 2008''

Revision as of 02:22, 28 July 2008

Image:1lep.png

Template:STRUCTURE 1lep

THREE-DIMENSIONAL STRUCTURE OF THE IMMUNODOMINANT HEAT-SHOCK PROTEIN CHAPERONIN-10 OF MYCOBACTERIUM LEPRAE

Template:ABSTRACT PUBMED 8539620

About this Structure

1LEP is a Single protein structure of sequence from Mycobacterium leprae. Full crystallographic information is available from OCA.

Reference

Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae., Mande SC, Mehra V, Bloom BR, Hol WG, Science. 1996 Jan 12;271(5246):203-7. PMID:8539620

Page seeded by OCA on Mon Jul 28 05:22:06 2008

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