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1q08

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[[Image:1q08.gif|left|200px]]
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{{Seed}}
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[[Image:1q08.png|left|200px]]
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{{STRUCTURE_1q08| PDB=1q08 | SCENE= }}
{{STRUCTURE_1q08| PDB=1q08 | SCENE= }}
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'''Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator, at 1.9 A resolution (space group P212121)'''
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===Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator, at 1.9 A resolution (space group P212121)===
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==Overview==
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The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10(-21) molar) sensitivity to free Cu+, which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn2+-sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
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The line below this paragraph, {{ABSTRACT_PUBMED_12958362}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12958362 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12958362}}
==About this Structure==
==About this Structure==
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[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
[[Category: Merr family transcriptional regulator]]
[[Category: Merr family transcriptional regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:42:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:22:17 2008''

Revision as of 02:22, 28 July 2008

Image:1q08.png

Template:STRUCTURE 1q08

Crystal structure of the Zn(II) form of E. coli ZntR, a zinc-sensing transcriptional regulator, at 1.9 A resolution (space group P212121)

Template:ABSTRACT PUBMED 12958362

About this Structure

1Q08 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR., Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A, Science. 2003 Sep 5;301(5638):1383-7. PMID:12958362

Page seeded by OCA on Mon Jul 28 05:22:17 2008

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