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1txz

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{{STRUCTURE_1txz| PDB=1txz | SCENE= }}
{{STRUCTURE_1txz| PDB=1txz | SCENE= }}
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'''Crystal structure of yeast ymx7, an ADP-ribose-1''-monophosphatase, complexed with ADP-ribose'''
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===Crystal structure of yeast ymx7, an ADP-ribose-1''-monophosphatase, complexed with ADP-ribose===
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==Overview==
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Appr-1''-pase, an important and ubiquitous cellular processing enzyme involved in the tRNA splicing pathway, catalyzes the conversion of ADP-ribose-1''monophosphate (Appr-1''-p) to ADP-ribose. The structures of the native enzyme from the yeast and its complex with ADP-ribose were determined to 1.9 A and 2.05 A, respectively. Analysis of the three-dimensional structure of this protein, selected as a target in a structural genomics project, reveals its putative function and provides clues to the catalytic mechanism. The structure of the 284-amino acid protein shows a two-domain architecture consisting of a three-layer alphabetaalpha sandwich N-terminal domain connected to a small C-terminal helical domain. The structure of Appr-1''-pase in complex with the product, ADP-ribose, reveals an active-site water molecule poised for nucleophilic attack on the terminal phosphate group. Loop-region residues Asn 80, Asp 90, and His 145 may form a catalytic triad.
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{{ABSTRACT_PUBMED_15722447}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Two domain organization]]
[[Category: Two domain organization]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:30:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:22:24 2008''

Revision as of 02:22, 28 July 2008

Image:1txz.png

Template:STRUCTURE 1txz

Crystal structure of yeast ymx7, an ADP-ribose-1-monophosphatase, complexed with ADP-ribose

Template:ABSTRACT PUBMED 15722447

About this Structure

1TXZ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of ADP-ribose-1-monophosphatase (Appr-1-pase), a ubiquitous cellular processing enzyme., Kumaran D, Eswaramoorthy S, Studier FW, Swaminathan S, Protein Sci. 2005 Mar;14(3):719-26. PMID:15722447

Page seeded by OCA on Mon Jul 28 05:22:24 2008

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