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1qcs

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{{STRUCTURE_1qcs| PDB=1qcs | SCENE= }}
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'''N-TERMINAL DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)'''
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===N-TERMINAL DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)===
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==Overview==
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N-ethylmaleimide-sensitive factor (NSF) is a hexameric ATPase essential for eukaryotic vesicle fusion. Along with SNAP proteins, it disassembles cis-SNARE complexes upon ATP hydrolysis, preparing SNAREs for trans complex formation. We have determined the crystal structure of the N-terminal domain of NSF (N) to 1.9 A resolution. N contains two subdomains which form a groove that is a likely SNAP interaction site. Unexpectedly, both N subdomains are structurally similar to domains in EF-Tu. Based on this similarity, we propose a model for a large conformational change in NSF that drives SNARE complex disassembly.
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(as it appears on PubMed at http://www.pubmed.gov), where 10445031 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10445031}}
==About this Structure==
==About this Structure==
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[[Category: Yu, R C.]]
[[Category: Yu, R C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:08:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:58:40 2008''

Revision as of 02:58, 28 July 2008

Template:STRUCTURE 1qcs

N-TERMINAL DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)

Template:ABSTRACT PUBMED 10445031

About this Structure

1QCS is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

NSF N-terminal domain crystal structure: models of NSF function., Yu RC, Jahn R, Brunger AT, Mol Cell. 1999 Jul;4(1):97-107. PMID:10445031

Page seeded by OCA on Mon Jul 28 05:58:40 2008

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