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1u08

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[[Image:1u08.gif|left|200px]]
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{{STRUCTURE_1u08| PDB=1u08 | SCENE= }}
{{STRUCTURE_1u08| PDB=1u08 | SCENE= }}
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'''Crystal Structure and Reactivity of YbdL from Escherichia coli Identify a Methionine Aminotransferase Function.'''
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===Crystal Structure and Reactivity of YbdL from Escherichia coli Identify a Methionine Aminotransferase Function.===
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==Overview==
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The ybdL gene of Escherichia coli codes for a protein of unknown function. Sequence analysis showed moderate homology to several vitamin B(6) dependent enzymes, suggesting that it may bind pyridoxal-5'-phosphate. The structure analysis of YbdL to 2.35 A resolution by protein crystallography verifies that it is a PLP dependent enzyme of fold type I, the typical aspartate aminotransferase fold. The active site contains a bound pyridoxal-5'-phosphate, covalently attached to the conserved active site lysine residue Lys236. The pattern of conserved amino acids in the putative substrate binding pocket of the enzyme reveals that it is most closely related to a hyperthermophilic aromatic residue aminotransferase from the archeon Pyrococcus horikoshii. Activity tests with 10 amino acids as amino-donors reveal, however, a preference for Met, followed by His and Phe, results which can be rationalized by modelization studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 15280032 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15280032}}
==About this Structure==
==About this Structure==
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[[Category: Tegoni, M.]]
[[Category: Tegoni, M.]]
[[Category: Alpha beta protein]]
[[Category: Alpha beta protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:35:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:16:54 2008''

Revision as of 03:17, 28 July 2008

Image:1u08.png

Template:STRUCTURE 1u08

Crystal Structure and Reactivity of YbdL from Escherichia coli Identify a Methionine Aminotransferase Function.

Template:ABSTRACT PUBMED 15280032

About this Structure

1U08 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function., Dolzan M, Johansson K, Roig-Zamboni V, Campanacci V, Tegoni M, Schneider G, Cambillau C, FEBS Lett. 2004 Jul 30;571(1-3):141-6. PMID:15280032

Page seeded by OCA on Mon Jul 28 06:16:54 2008

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