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1x7q

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[[Image:1x7q.gif|left|200px]]
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{{STRUCTURE_1x7q| PDB=1x7q | SCENE= }}
{{STRUCTURE_1x7q| PDB=1x7q | SCENE= }}
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'''Crystal structure of HLA-A*1101 with sars nucleocapsid peptide'''
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===Crystal structure of HLA-A*1101 with sars nucleocapsid peptide===
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==Overview==
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The structure of the human MHC-I molecule HLA-A*1101 in complex with a nonameric peptide (KTFPPTEPK) has been determined by X-ray crystallography to 1.45 A resolution. The peptide is derived from the SARS-CoV nucleocapsid protein positions 362-370 (SNP362-370). It is conserved in all known isolates of SARS-CoV and has been verified by in vitro peptide-binding studies to be a good to intermediate binder to HLA-A*0301 and HLA-A*1101, with IC50 values of 70 and 186 nM, respectively [Sylvester-Hvid et al. (2004), Tissue Antigens, 63, 395-400]. In terms of the residues lining the peptide-binding groove, the HLA-A*1101-SNP362-370 complex is very similar to other known structures of HLA-A*1101 and HLA-A*6801. The SNP362-370 peptide is held in place by 17 hydrogen bonds to the alpha-chain residues and by nine water molecules which are also tightly bound in the peptide-binding groove. Thr6 of the peptide (Thr6p) does not make efficient use of the middle (E) pocket. For vaccine development, there seems to be a potential for optimization targeted at this position. All residues except Thr2p and Lys9p are accessible for T-cell recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_16041067}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16041067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16041067}}
==About this Structure==
==About this Structure==
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[[Category: Peptide-mhc-complex]]
[[Category: Peptide-mhc-complex]]
[[Category: Sar]]
[[Category: Sar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:40:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:33:26 2008''

Revision as of 03:33, 28 July 2008

Image:1x7q.png

Template:STRUCTURE 1x7q

Crystal structure of HLA-A*1101 with sars nucleocapsid peptide

Template:ABSTRACT PUBMED 16041067

About this Structure

1X7Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide., Blicher T, Kastrup JS, Buus S, Gajhede M, Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1031-40. Epub 2005, Jul 20. PMID:16041067

Page seeded by OCA on Mon Jul 28 06:33:26 2008

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