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2a2u

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[[Image:2a2u.gif|left|200px]]
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{{STRUCTURE_2a2u| PDB=2a2u | SCENE= }}
{{STRUCTURE_2a2u| PDB=2a2u | SCENE= }}
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'''THE CRYSTAL STRUCTURES OF A2U-GLOBULIN AND ITS COMPLEX WITH A HYALINE DROPLET INDUCER.'''
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===THE CRYSTAL STRUCTURES OF A2U-GLOBULIN AND ITS COMPLEX WITH A HYALINE DROPLET INDUCER.===
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==Overview==
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Alpha 2u-globulin (A2U) is the major urinary protein excreted by adult male rats. The structure of a monoclinic crystal form of A2U was reported in 1992 [Bocskei et al. (1992). Nature (London), 360, 186-188]. The structures of an orthorhombic crystal form of A2U at 2. 5 A resolution (refined to an R factor of 0.248; Rfree = 0.264) and of a complex between A2U and d-limonene 1,2-epoxide (DLO) at 2.9 A resolution (R factor = 0.248; Rfree = 0.260) are presented here. DLO is one of a diverse group of chemicals which cause a male rat-specific renal carcinogenesis called hyaline-droplet nephropathy. The rate-determining step in the development of this disorder is the binding of the toxin to A2U. Comparison of the cavities in A2U and in the corresponding mouse urinary protein (MUP) reveal that the former is tailor-made for small oval hydrophobic ligands such as DLO. The cavity in MUP is more shallow and elongated and cannot easily accommodate such ligands.
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(as it appears on PubMed at http://www.pubmed.gov), where 10089305 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10089305}}
==About this Structure==
==About this Structure==
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[[Category: Kleywegt, G J.]]
[[Category: Kleywegt, G J.]]
[[Category: A2u-globulin]]
[[Category: A2u-globulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:31:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:37:49 2008''

Revision as of 03:37, 28 July 2008

Image:2a2u.png

Template:STRUCTURE 2a2u

THE CRYSTAL STRUCTURES OF A2U-GLOBULIN AND ITS COMPLEX WITH A HYALINE DROPLET INDUCER.

Template:ABSTRACT PUBMED 10089305

About this Structure

2A2U is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structures of alpha 2u-globulin and its complex with a hyaline droplet inducer., Chaudhuri BN, Kleywegt GJ, Bjorkman J, Lehman-McKeeman LD, Oliver JD, Jones TA, Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):753-62. PMID:10089305

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