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2pqu

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{{STRUCTURE_2pqu| PDB=2pqu | SCENE= }}
{{STRUCTURE_2pqu| PDB=2pqu | SCENE= }}
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'''Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer telomeric dna'''
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===Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer telomeric dna===
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==Overview==
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Poly(C)-binding proteins (PCBPs) are KH (hnRNP K homology) domain-containing proteins that recognize poly(C) DNA and RNA sequences in mammalian cells. Binding poly(C) sequences via the KH domains is critical for PCBP functions. To reveal the mechanisms of KH domain-D/RNA recognition and its functional importance, we have determined the crystal structures of PCBP2 KH1 domain in complex with a 12-nucleotide DNA corresponding to two repeats of the human C-rich strand telomeric DNA and its RNA equivalent. The crystal structures reveal molecular details for not only KH1-DNA/RNA interaction but also protein-protein interaction between two KH1 domains. NMR studies on a protein construct containing two KH domains (KH1 + KH2) of PCBP2 indicate that KH1 interacts with KH2 in a way similar to the KH1-KH1 interaction. The crystal structures and NMR data suggest possible ways by which binding certain nucleic acid targets containing tandem poly(C) motifs may induce structural rearrangement of the KH domains in PCBPs; such structural rearrangement may be crucial for some PCBP functions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17526645 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17526645}}
==About this Structure==
==About this Structure==
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[[Category: Lee, J.]]
[[Category: Lee, J.]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna binding protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:38:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:02:48 2008''

Revision as of 04:02, 28 July 2008

Image:2pqu.png

Template:STRUCTURE 2pqu

Crystal structure of KH1 domain of human PCBP2 complexed to single-stranded 12-mer telomeric dna

Template:ABSTRACT PUBMED 17526645

About this Structure

2PQU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic and NMR studies of protein-protein and protein-nucleic acid interactions involving the KH domains from human poly(C)-binding protein-2., Du Z, Lee JK, Fenn S, Tjhen R, Stroud RM, James TL, RNA. 2007 Jul;13(7):1043-51. Epub 2007 May 25. PMID:17526645

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