This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r59

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1r59.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1r59.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1r59| PDB=1r59 | SCENE= }}
{{STRUCTURE_1r59| PDB=1r59 | SCENE= }}
-
'''Enterococcus casseliflavus glycerol kinase'''
+
===Enterococcus casseliflavus glycerol kinase===
-
==Overview==
+
<!--
-
The first structure of a glycerol kinase from a Gram-positive organism, Enterococcus casseliflavus, has been determined to 2.8 A resolution in the presence of glycerol and to 2.5 A resolution in the absence of substrate. The substrate-induced closure of 7 degrees is significantly smaller than that reported for hexokinase, a model for substrate-mediated domain closure that has been proposed for glycerol kinase. Despite the 78% level of sequence identity and conformational similarity in the catalytic cleft regions of the En. casseliflavus and Escherichia coli glycerol kinases, remarkable structural differences have now been identified. These differences correlate well with their divergent regulatory schemes of activation by phosphorylation in En. casseliflavus and allosteric inhibition in E. coli. On the basis of our structural results, we propose a mechanism by which the phosphorylation of a histidyl residue located 25 A from the active site results in a 10-15-fold increase in the activity of the enterococcal glycerol kinase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14717590}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14717590 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14717590}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Yeh, J I.]]
[[Category: Yeh, J I.]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:05:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:08:33 2008''

Revision as of 04:08, 28 July 2008

Image:1r59.png

Template:STRUCTURE 1r59

Enterococcus casseliflavus glycerol kinase

Template:ABSTRACT PUBMED 14717590

About this Structure

1R59 is a Single protein structure of sequence from Enterococcus casseliflavus. Full crystallographic information is available from OCA.

Reference

Structures of enterococcal glycerol kinase in the absence and presence of glycerol: correlation of conformation to substrate binding and a mechanism of activation by phosphorylation., Yeh JI, Charrier V, Paulo J, Hou L, Darbon E, Claiborne A, Hol WG, Deutscher J, Biochemistry. 2004 Jan 20;43(2):362-73. PMID:14717590

Page seeded by OCA on Mon Jul 28 07:08:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r59"
Personal tools