1pc9

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{{STRUCTURE_1pc9| PDB=1pc9 | SCENE= }}
{{STRUCTURE_1pc9| PDB=1pc9 | SCENE= }}
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'''Crystal Structure of BnSP-6, a Lys49-Phospholipase A2'''
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===Crystal Structure of BnSP-6, a Lys49-Phospholipase A2===
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==Overview==
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Phospholipases A(2) are components of Bothrops venoms responsible for disruption of cell membrane integrity via hydrolysis of its phospholipids. A class of PLA(2)-like proteins has been described which despite PLA(2) activity on artificial substrate, due to a D49K mutation, is still highly myonecrotic. This work reports the X-ray structure determination of two Lys49-PLA(2)s from Bothrops neuwiedi pauloensis (BnSP-7 and BnSP-6) and, for the first time, the comparison of eight dimeric Lys49-PLA(2)s. This comparison reveals that there are not just two ("open" and "closed") but at least six different conformations. The binding of fatty acid observed in three recent Lys49-PLA(2) structures seems to be independent of their quaternary conformation. Cys29 polarization by Lys122 is not significant for BnSP-7 and BnSP-6 or other structures not bound by fatty acids. These structures may be in an "active" state when nothing is bound to them and the Lys122/Cys29 interactions are weak or absent.
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{{ABSTRACT_PUBMED_14623331}}
==About this Structure==
==About this Structure==
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[[Category: Myotoxin]]
[[Category: Myotoxin]]
[[Category: Venom.]]
[[Category: Venom.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:55:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:29:10 2008''

Revision as of 04:29, 28 July 2008

Image:1pc9.png

Template:STRUCTURE 1pc9

Crystal Structure of BnSP-6, a Lys49-Phospholipase A2

Template:ABSTRACT PUBMED 14623331

About this Structure

1PC9 is a Single protein structure of sequence from Bothrops neuwiedi pauloensis. Full crystallographic information is available from OCA.

Reference

Crystal structures of BnSP-7 and BnSP-6, two Lys49-phospholipases A(2): quaternary structure and inhibition mechanism insights., Magro AJ, Soares AM, Giglio JR, Fontes MR, Biochem Biophys Res Commun. 2003 Nov 21;311(3):713-20. PMID:14623331

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