This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1z91

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1z91.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1z91.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1z91| PDB=1z91 | SCENE= }}
{{STRUCTURE_1z91| PDB=1z91 | SCENE= }}
-
'''x-ray crystal structure of apo-OhrRC15S in reduced form: MarR family protein'''
+
===x-ray crystal structure of apo-OhrRC15S in reduced form: MarR family protein===
-
==Overview==
+
<!--
-
The mechanisms by which Bacillus subtilis OhrR, a member of the MarR family of transcription regulators, binds the ohrA operator and is induced by oxidation of its lone cysteine residue by organic hydroperoxides to sulphenic acid are unknown. Here, we describe the crystal structures of reduced OhrR and an OhrR-ohrA operator complex. To bind DNA, OhrR employs a chimeric winged helix-turn-helix DNA binding motif, which is composed of extended eukaryotic-like wings, prokaryotic helix-turn-helix motifs, and helix-helix elements. The reactivity of the peroxide-sensing cysteine is not modulated by proximal basic residues but largely by the positive dipole of helix alpha1. Induction originates from the alleviation of intersubunit steric clash between the sulphenic acid moieties of the oxidized sensor cysteines and nearby tyrosines and methionines. The structure of the OhrR-ohrA operator complex reveals the DNA binding mechanism of the entire MarR family and suggests a common inducer binding pocket.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16209951}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16209951 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16209951}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Marr family]]
[[Category: Marr family]]
[[Category: Ohrr]]
[[Category: Ohrr]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:19:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:40:54 2008''

Revision as of 04:40, 28 July 2008

Image:1z91.png

Template:STRUCTURE 1z91

x-ray crystal structure of apo-OhrRC15S in reduced form: MarR family protein

Template:ABSTRACT PUBMED 16209951

About this Structure

1Z91 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family., Hong M, Fuangthong M, Helmann JD, Brennan RG, Mol Cell. 2005 Oct 7;20(1):131-41. PMID:16209951

Page seeded by OCA on Mon Jul 28 07:40:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z91"
Personal tools