1o76

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[[Image:1o76.jpg|left|200px]]
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{{STRUCTURE_1o76| PDB=1o76 | SCENE= }}
{{STRUCTURE_1o76| PDB=1o76 | SCENE= }}
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'''CYANIDE COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA'''
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===CYANIDE COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA===
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==Overview==
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The crystal structure of the ternary cyanide complex of P450cam and camphor was determined to 1.8A resolution and found to be identical with the structure of the active oxygen complex [I. Schlichting et al., 2000, Science 287, 1615]. Notably, cyanide binds in a bent mode and induces the active conformation that is characterized by the presence of two water molecules and a flip of the carbonyl of the conserved Asp251. The structure of the ternary complex of cyanide, L-arginine, and the oxygenase domain of inducible nitric oxide synthase was determined to 2.4A resolution. Cyanide binds essentially linearly, interacts with L-Arg, and induces the binding of a water molecule at the active site. This water is positioned by backbone interactions, located 2.8A from the nitrogen atom of cyanide, and could provide a proton required for O-O bond scission in the hydroxylation reaction of nitric oxide synthase.
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(as it appears on PubMed at http://www.pubmed.gov), where 12464241 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12464241}}
==About this Structure==
==About this Structure==
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[[Category: Mono-oxygenase]]
[[Category: Mono-oxygenase]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:28:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:45:23 2008''

Revision as of 04:45, 28 July 2008

Image:1o76.png

Template:STRUCTURE 1o76

CYANIDE COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA

Template:ABSTRACT PUBMED 12464241

About this Structure

1O76 is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes., Fedorov R, Ghosh DK, Schlichting I, Arch Biochem Biophys. 2003 Jan 1;409(1):25-31. PMID:12464241

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