1s35

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1s35.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1s35.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1s35| PDB=1s35 | SCENE= }}
{{STRUCTURE_1s35| PDB=1s35 | SCENE= }}
-
'''Crystal Structure of Repeats 8 and 9 of Human Erythroid Spectrin'''
+
===Crystal Structure of Repeats 8 and 9 of Human Erythroid Spectrin===
-
==Overview==
+
<!--
-
Erythroid spectrin, a major component of the cytoskeletal network of the red cell which contributes to both the stability and the elasticity of the red cell membrane, is composed of two subunits, alpha and beta, each formed by 16-20 tandem repeats. The properties of the repeats and their relative arrangement are thought to be key determinants of spectrin flexibility. Here we report a 2.4 A resolution crystal structure of human erythroid beta-spectrin repeats 8 and 9. This two-repeat fragment is unusual as it exhibits low stability of folding and one of its repeats lacks two tryptophans highly conserved among spectrin repeats. Two key factors responsible for the lower stability and, possibly, its flexibility, are revealed by the structure. A third novel feature of the structure is the relative orientation of the two repeats, which increases the range of possible conformations and provides new insights into atomic models of spectrin flexibility.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15062087}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15062087 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15062087}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Beta spectrin]]
[[Category: Beta spectrin]]
[[Category: Two repeats of spectrin]]
[[Category: Two repeats of spectrin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:14:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:58:04 2008''

Revision as of 04:58, 28 July 2008

Image:1s35.png

Template:STRUCTURE 1s35

Crystal Structure of Repeats 8 and 9 of Human Erythroid Spectrin

Template:ABSTRACT PUBMED 15062087

About this Structure

1S35 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insights into the stability and flexibility of unusual erythroid spectrin repeats., Kusunoki H, MacDonald RI, Mondragon A, Structure. 2004 Apr;12(4):645-56. PMID:15062087

Page seeded by OCA on Mon Jul 28 07:58:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1s35"
Personal tools