1oxy

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{{STRUCTURE_1oxy| PDB=1oxy | SCENE= }}
{{STRUCTURE_1oxy| PDB=1oxy | SCENE= }}
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'''CRYSTALLOGRAPHIC ANALYSIS OF OXYGENATED AND DEOXYGENATED STATES OF ARTHROPOD HEMOCYANIN SHOWS UNUSUAL DIFFERENCES'''
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===CRYSTALLOGRAPHIC ANALYSIS OF OXYGENATED AND DEOXYGENATED STATES OF ARTHROPOD HEMOCYANIN SHOWS UNUSUAL DIFFERENCES===
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==Overview==
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The X-ray structure of an oxygenated hemocyanin molecule, subunit II of Limulus polyphemus hemocyanin, was determined at 2.4 A resolution and refined to a crystallographic R-factor of 17.1%. The 73-kDa subunit crystallizes with the symmetry of the space group R32 with one subunit per asymmetric unit forming hexamers with 32 point group symmetry. Molecular oxygen is bound to a dinuclear copper center in the protein's second domain, symmetrically between and equidistant from the two copper atoms. The copper-copper distance in oxygenated Limulus hemocyanin is 3.6 +/- 0.2 A, which is surprisingly 1 A less than that seen previously in deoxygenated Limulus polyphemus subunit II hemocyanin (Hazes et al., Protein Sci. 2:597, 1993). Away from the oxygen binding sites, the tertiary and quaternary structures of oxygenated and deoxygenated Limulus subunit II hemocyanins are quite similar. A major difference in tertiary structures is seen, however, when the Limulus structures are compared with deoxygenated Panulirus interruptus hemocyanin (Volbeda, A., Hol, W.G.J.J. Mol. Biol. 209:249, 1989) where the position of domain 1 is rotated by 8 degrees with respect to domains 2 and 3. We postulate this rotation plays an important role in cooperativity and regulation of oxygen affinity in all arthropod hemocyanins.
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{{ABSTRACT_PUBMED_7984626}}
==About this Structure==
==About this Structure==
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[[Category: Ton-that, H.]]
[[Category: Ton-that, H.]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:03:59 2008''

Revision as of 05:04, 28 July 2008

Image:1oxy.png

Template:STRUCTURE 1oxy

CRYSTALLOGRAPHIC ANALYSIS OF OXYGENATED AND DEOXYGENATED STATES OF ARTHROPOD HEMOCYANIN SHOWS UNUSUAL DIFFERENCES

Template:ABSTRACT PUBMED 7984626

About this Structure

1OXY is a Single protein structure of sequence from Limulus polyphemus. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences., Magnus KA, Hazes B, Ton-That H, Bonaventura C, Bonaventura J, Hol WG, Proteins. 1994 Aug;19(4):302-9. PMID:7984626

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