1qtp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1qtp.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1qtp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1qtp| PDB=1qtp | SCENE= }}
{{STRUCTURE_1qtp| PDB=1qtp | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE'''
+
===CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE===
-
==Overview==
+
<!--
-
AP-2 adaptors regulate clathrin-bud formation at the cell surface by recruiting clathrin trimers to the plasma membrane and by selecting certain membrane proteins for inclusion within the developing clathrin-coat structure. These functions are performed by discrete subunits of the adaptor heterotetramer. The carboxyl-terminal appendage of the AP-2 alpha subunit appears to regulate the translocation of several endocytic accessory proteins to the bud site. We have determined the crystal structure of the alpha appendage at 1.4-A resolution by multiwavelength anomalous diffraction phasing. It is composed of two distinct structural modules, a beta-sandwich domain and a mixed alpha-beta platform domain. Structure-based mutagenesis shows that alterations to the molecular surface of a highly conserved region on the platform domain differentially affect associations of the appendage with amphiphysin, eps15, epsin, and AP180, revealing a common protein-binding interface.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10430869}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10430869 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10430869}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Selenomethionine]]
[[Category: Selenomethionine]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:41:34 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:10:24 2008''

Revision as of 05:10, 28 July 2008

Image:1qtp.png

Template:STRUCTURE 1qtp

CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE

Template:ABSTRACT PUBMED 10430869

About this Structure

1QTP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly., Traub LM, Downs MA, Westrich JL, Fremont DH, Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8907-12. PMID:10430869

Page seeded by OCA on Mon Jul 28 08:10:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qtp"
Personal tools