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1qlf

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[[Image:1qlf.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1qlf| PDB=1qlf | SCENE= }}
{{STRUCTURE_1qlf| PDB=1qlf | SCENE= }}
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'''MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G'''
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===MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G===
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==Overview==
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Two synthetic O-GlcNAc-bearing peptides that elicit H-2Db-restricted glycopeptide-specific cytotoxic T cells (CTL) have been shown to display nonreciprocal patterns of cross-reactivity. Here, we present the crystal structures of the H-2Db glycopeptide complexes to 2.85 A resolution or better. In both cases, the glycan is solvent exposed and available for direct recognition by the T cell receptor (TCR). We have modeled the complex formed between the MHC-glycopeptide complexes and their respective TCRs, showing that a single saccharide residue can be accommodated in the standard TCR-MHC geometry. The models also reveal a possible molecular basis for the observed cross-reactivity patterns of the CTL clones, which appear to be influenced by the length of the CDR3 loop and the nature of the immunizing ligand.
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(as it appears on PubMed at http://www.pubmed.gov), where 10023771 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10023771}}
==About this Structure==
==About this Structure==
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[[Category: Immunology]]
[[Category: Immunology]]
[[Category: Mhc]]
[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:24:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:30:11 2008''

Revision as of 05:30, 28 July 2008

Image:1qlf.png

Template:STRUCTURE 1qlf

MHC CLASS I H-2DB COMPLEXED WITH GLYCOPEPTIDE K3G

Template:ABSTRACT PUBMED 10023771

About this Structure

1QLF is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Sendai virus. Full crystallographic information is available from OCA.

Reference

Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity., Glithero A, Tormo J, Haurum JS, Arsequell G, Valencia G, Edwards J, Springer S, Townsend A, Pao YL, Wormald M, Dwek RA, Jones EY, Elliott T, Immunity. 1999 Jan;10(1):63-74. PMID:10023771

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