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1wyu

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{{STRUCTURE_1wyu| PDB=1wyu | SCENE= }}
{{STRUCTURE_1wyu| PDB=1wyu | SCENE= }}
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'''Crystal structure of glycine decarboxylase (P-protein) of the glycine cleavage system, in holo form'''
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===Crystal structure of glycine decarboxylase (P-protein) of the glycine cleavage system, in holo form===
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==Overview==
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The crystal structure of the P-protein of the glycine cleavage system from Thermus thermophilus HB8 has been determined. This is the first reported crystal structure of a P-protein, and it reveals that P-proteins do not involve the alpha(2)-type active dimer universally observed in the evolutionarily related pyridoxal 5'-phosphate (PLP)-dependent enzymes. Instead, novel alphabeta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The binding of PLP to the apoenzyme induces large open-closed conformational changes, with residues moving up to 13.5 A. The structure of the complex formed by the holoenzyme bound to an inhibitor, (aminooxy)acetate, suggests residues that may be responsible for substrate recognition. The molecular surface around the lipoamide-binding channel shows conservation of positively charged residues, which are possibly involved in complex formation with the H-protein. These results provide insights into the molecular basis of nonketotic hyperglycinemia.
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(as it appears on PubMed at http://www.pubmed.gov), where 15791207 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15791207}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:19:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:38:54 2008''

Revision as of 05:38, 28 July 2008

Image:1wyu.png

Template:STRUCTURE 1wyu

Crystal structure of glycine decarboxylase (P-protein) of the glycine cleavage system, in holo form

Template:ABSTRACT PUBMED 15791207

About this Structure

1WYU is a Protein complex structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia., Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N, EMBO J. 2005 Apr 20;24(8):1523-36. Epub 2005 Mar 24. PMID:15791207

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