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1r4x

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{{STRUCTURE_1r4x| PDB=1r4x | SCENE= }}
{{STRUCTURE_1r4x| PDB=1r4x | SCENE= }}
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'''Crystal Structure Analys of the Gamma-COPI Appendage domain'''
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===Crystal Structure Analys of the Gamma-COPI Appendage domain===
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==Overview==
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COPI-coated vesicles mediate retrograde transport from the Golgi back to the ER and intra-Golgi transport. The cytosolic precursor of the COPI coat, the heptameric coatomer complex, can be thought of as composed of two subcomplexes. The first consists of the beta-, gamma-, delta- and zeta-COP subunits which are distantly homologous to AP clathrin adaptor subunits. The second consists of the alpha-, beta'- and epsilon-COP subunits. Here, we present the structure of the appendage domain of gamma-COP and show that it has a similar overall fold as the alpha-appendage of AP2. Again, like the alpha-appendage the gamma-COP appendage possesses a single protein/protein interaction site on its platform subdomain. We show that in yeast this site binds to the ARFGAP Glo3p, and in mammalian gamma-COP this site binds to a Glo3p orthologue, ARFGAP2. On the basis of mutations in the yeast homologue of gamma-COP, Sec21p, a second binding site is proposed to exist on the gamma-COP appendage that interacts with the alpha,beta',epsilon COPI subcomplex.
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(as it appears on PubMed at http://www.pubmed.gov), where 14690497 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14690497}}
==About this Structure==
==About this Structure==
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Coatomer]]
[[Category: Coatomer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:04:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:49:38 2008''

Revision as of 05:49, 28 July 2008

Image:1r4x.png

Template:STRUCTURE 1r4x

Crystal Structure Analys of the Gamma-COPI Appendage domain

Template:ABSTRACT PUBMED 14690497

About this Structure

1R4X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Gamma-COP appendage domain - structure and function., Watson PJ, Frigerio G, Collins BM, Duden R, Owen DJ, Traffic. 2004 Feb;5(2):79-88. PMID:14690497

Page seeded by OCA on Mon Jul 28 08:49:38 2008

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