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2evo

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{{STRUCTURE_2evo| PDB=2evo | SCENE= }}
{{STRUCTURE_2evo| PDB=2evo | SCENE= }}
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'''crystal structure of methionine amino peptidase in complex with N-cyclopentyl-N-(thiazol-2-yl)oxalamide'''
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===crystal structure of methionine amino peptidase in complex with N-cyclopentyl-N-(thiazol-2-yl)oxalamide===
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==Overview==
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One of the challenges in the development of methionine aminopeptidase (MetAP) inhibitors as antibacterial and anticancer agents is to define the metal ion actually used by MetAP in vivo and to discover MetAP inhibitors that can inhibit the metalloform that is relevant in vivo. Two distinct classes of novel nonpeptidic MetAP inhibitors that are not only potent but also highly selective for either the Mn(II) or Co(II) form have been identified. Three crystal structures of Escherichia coli MetAP complexed with the metalloform-selective inhibitors 5-(2,5-dichlorophenyl)furan-2-carboxylic acid (2), 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid (3) and N-cyclopentyl-N-(thiazol-2-yl)oxalamide (4) have been solved and analysis of these structures has revealed the structural basis for their metalloform-selective inhibition. The Mn(II)-form selective inhibitors (2) and (3) both use their carboxylate group to coordinate with the two Mn(II) ions at the dinuclear metal site and both adopt a non-coplanar conformation for the two aromatic rings. The unique coordination geometry of these inhibitors may determine their Mn(II)-form selectivity. In contrast, the Co(II)-form selective inhibitor (4) recruits an unexpected third metal ion, forming a trimetallic enzyme-metal-inhibitor complex. Thus, an important factor in the selectivity of (4) for the Co(II) form may be a consequence of a greater preference for a softer N,O-donor ligand for the softer Co(II).
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(as it appears on PubMed at http://www.pubmed.gov), where 16552144 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16552144}}
==About this Structure==
==About this Structure==
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[[Category: Complex]]
[[Category: Complex]]
[[Category: Methionine aminopeptidase]]
[[Category: Methionine aminopeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:28:04 2008''

Revision as of 06:28, 28 July 2008

Image:2evo.png

Template:STRUCTURE 2evo

crystal structure of methionine amino peptidase in complex with N-cyclopentyl-N-(thiazol-2-yl)oxalamide

Template:ABSTRACT PUBMED 16552144

About this Structure

2EVO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural analysis of metalloform-selective inhibition of methionine aminopeptidase., Xie SX, Huang WJ, Ma ZQ, Huang M, Hanzlik RP, Ye QZ, Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):425-32. Epub 2006, Mar 18. PMID:16552144

Page seeded by OCA on Mon Jul 28 09:28:04 2008

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