2e7z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2e7z.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2e7z.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2e7z| PDB=2e7z | SCENE= }}
{{STRUCTURE_2e7z| PDB=2e7z | SCENE= }}
-
'''Acetylene Hydratase from Pelobacter acetylenicus'''
+
===Acetylene Hydratase from Pelobacter acetylenicus===
-
==Overview==
+
<!--
-
The tungsten-iron-sulfur enzyme acetylene hydratase stands out from its class because it catalyzes a nonredox reaction, the hydration of acetylene to acetaldehyde. Sequence comparisons group the protein into the dimethyl sulfoxide reductase family, and it contains a bis-molybdopterin guanine dinucleotide-ligated tungsten atom and a cubane-type [4Fe:4S] cluster. The crystal structure of acetylene hydratase at 1.26 A now shows that the tungsten center binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct, hydrophobic pocket. This mechanism requires a strong shift of pK(a) of the aspartate, caused by a nearby low-potential [4Fe:4S] cluster. To access this previously unrecognized W-Asp active site, the protein evolved a new substrate channel distant from where it is found in other molybdenum and tungsten enzymes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17360611}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17360611 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17360611}}
==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase., Seiffert GB, Ullmann GM, Messerschmidt A, Schink B, Kroneck PM, Einsle O, Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3073-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17360611 17360611]
Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase., Seiffert GB, Ullmann GM, Messerschmidt A, Schink B, Kroneck PM, Einsle O, Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3073-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17360611 17360611]
 +
 +
Crystallization and preliminary X-ray analysis of the tungsten-dependent acetylene hydratase from Pelobacter acetylenicus., Einsle O, Niessen H, Abt DJ, Seiffert G, Schink B, Huber R, Messerschmidt A, Kroneck PM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):299-301. Epub 2005 Feb 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511024 16511024]
[[Category: Deleted entry]]
[[Category: Deleted entry]]
[[Category: Pelobacter acetylenicus]]
[[Category: Pelobacter acetylenicus]]
Line 30: Line 36:
[[Category: Iron-sulfur-cluster]]
[[Category: Iron-sulfur-cluster]]
[[Category: Tungstoprotein]]
[[Category: Tungstoprotein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:06:23 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:34:31 2008''

Revision as of 06:34, 28 July 2008

Image:2e7z.png

Template:STRUCTURE 2e7z

Acetylene Hydratase from Pelobacter acetylenicus

Template:ABSTRACT PUBMED 17360611

About this Structure

2E7Z is a Single protein structure of sequence from Pelobacter acetylenicus. Full crystallographic information is available from OCA.

Reference

Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase., Seiffert GB, Ullmann GM, Messerschmidt A, Schink B, Kroneck PM, Einsle O, Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3073-7. PMID:17360611

Crystallization and preliminary X-ray analysis of the tungsten-dependent acetylene hydratase from Pelobacter acetylenicus., Einsle O, Niessen H, Abt DJ, Seiffert G, Schink B, Huber R, Messerschmidt A, Kroneck PM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):299-301. Epub 2005 Feb 12. PMID:16511024

Page seeded by OCA on Mon Jul 28 09:34:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2e7z"
Personal tools