2qe4

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{{STRUCTURE_2qe4| PDB=2qe4 | SCENE= }}
{{STRUCTURE_2qe4| PDB=2qe4 | SCENE= }}
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'''Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist'''
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===Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist===
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==Overview==
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Benzopyrans are selective estrogen receptor (ER) beta agonists (SERBAs), which bind the ER receptor subtypes alpha and beta in opposite orientations. We have used structure based drug design to show that this unique phenomena can be exploited via substitution at the 8-position of the benzopyran A-ring to disrupt binding to ERalpha, thus improving ERbeta subtype selectivity. X-ray cocrystal structures with ERalpha and ERbeta are supportive of this approach to improve selectivity in this structural class.
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(as it appears on PubMed at http://www.pubmed.gov), where 17662603 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17662603}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:47:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:07:22 2008''

Revision as of 07:07, 28 July 2008

Image:2qe4.png

Template:STRUCTURE 2qe4

Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist

Template:ABSTRACT PUBMED 17662603

About this Structure

2QE4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 4: functionalization of the benzopyran A-ring., Norman BH, Richardson TI, Dodge JA, Pfeifer LA, Durst GL, Wang Y, Durbin JD, Krishnan V, Dinn SR, Liu S, Reilly JE, Ryter KT, Bioorg Med Chem Lett. 2007 Sep 15;17(18):5082-5. Epub 2007 Jul 13. PMID:17662603

Page seeded by OCA on Mon Jul 28 10:07:22 2008

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