This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ez6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ez6.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ez6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ez6| PDB=2ez6 | SCENE= }}
{{STRUCTURE_2ez6| PDB=2ez6 | SCENE= }}
-
'''Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing'''
+
===Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing===
-
==Overview==
+
<!--
-
Members of the ribonuclease III (RNase III) family are double-stranded RNA (dsRNA) specific endoribonucleases characterized by a signature motif in their active centers and a two-base 3' overhang in their products. While Dicer, which produces small interfering RNAs, is currently the focus of intense interest, the structurally simpler bacterial RNase III serves as a paradigm for the entire family. Here, we present the crystal structure of an RNase III-product complex, the first catalytic complex observed for the family. A 7 residue linker within the protein facilitates induced fit in protein-RNA recognition. A pattern of protein-RNA interactions, defined by four RNA binding motifs in RNase III and three protein-interacting boxes in dsRNA, is responsible for substrate specificity, while conserved amino acid residues and divalent cations are responsible for scissile-bond cleavage. The structure reveals a wealth of information about the mechanism of RNA hydrolysis that can be extrapolated to other RNase III family members.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16439209}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16439209 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16439209}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Rna interference]]
[[Category: Rna interference]]
[[Category: Rna processing]]
[[Category: Rna processing]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:16:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:09:41 2008''

Revision as of 07:09, 28 July 2008

Image:2ez6.png

Template:STRUCTURE 2ez6

Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing

Template:ABSTRACT PUBMED 16439209

About this Structure

2EZ6 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III., Gan J, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X, Cell. 2006 Jan 27;124(2):355-66. PMID:16439209

Page seeded by OCA on Mon Jul 28 10:09:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ez6"
Personal tools