This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2j4o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2j4o.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2j4o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2j4o| PDB=2j4o | SCENE= }}
{{STRUCTURE_2j4o| PDB=2j4o | SCENE= }}
-
'''STRUCTURE OF TAB1'''
+
===STRUCTURE OF TAB1===
-
==Overview==
+
<!--
-
TAB1 [TAK1 (transforming growth factor-beta-activated kinase 1)-binding protein 1] is one of the regulatory subunits of TAK1, a protein kinase that lies at the head of three pro-inflammatory kinase cascades. In the current study we report the crystal structure of the N-terminal domain of TAB1. Surprisingly, TAB1 possesses a fold closely related to that of the PPM (Mg2+- or Mn2+-dependent protein phosphatase) family as demonstrated by the close structural similarity with protein phosphatase 2C alpha. However, we were unable to detect any phosphatase activity for TAB1 using a phosphopeptide or p-nitrophenyl phosphate as substrate. Although the overall protein phosphatase 2C alpha fold is conserved in TAB1, detailed structural analyses and mutagenesis studies show that several key residues required for dual metal-binding and catalysis are not present in TAB1, although binding of a single metal is supported by soaking experiments with manganese and isothermal titration calorimetry. Thus, it appears that TAB1 is a 'pseudophosphatase', possibly binding to and regulating accessibility of phosphorylated residues on substrates downstream of TAK1 or on the TAK1 complex itself.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16879102}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16879102 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16879102}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Tak1 binding protein]]
[[Category: Tak1 binding protein]]
[[Category: Tgf-beta]]
[[Category: Tgf-beta]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:19:48 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:22:03 2008''

Revision as of 07:22, 28 July 2008

Image:2j4o.png

Template:STRUCTURE 2j4o

STRUCTURE OF TAB1

Template:ABSTRACT PUBMED 16879102

About this Structure

2J4O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

TAK1-binding protein 1 is a pseudophosphatase., Conner SH, Kular G, Peggie M, Shepherd S, Schuttelkopf AW, Cohen P, Van Aalten DM, Biochem J. 2006 Nov 1;399(3):427-34. PMID:16879102

Page seeded by OCA on Mon Jul 28 10:22:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j4o"
Personal tools