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1u35

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{{STRUCTURE_1u35| PDB=1u35 | SCENE= }}
{{STRUCTURE_1u35| PDB=1u35 | SCENE= }}
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'''Crystal structure of the nucleosome core particle containing the histone domain of macroH2A'''
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===Crystal structure of the nucleosome core particle containing the histone domain of macroH2A===
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==Overview==
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macroH2A is an H2A variant with a highly unusual structural organization. It has a C-terminal domain connected to the N-terminal histone domain by a linker. Crystallographic and biochemical studies show that changes in the L1 loop in the histone fold region of macroH2A impact the structure and potentially the function of nucleosomes. The 1.6-A X-ray structure of the nonhistone region reveals an alpha/beta fold which has previously been found in a functionally diverse group of proteins. This region associates with histone deacetylases and affects the acetylation status of nucleosomes containing macroH2A. Thus, the unusual domain structure of macroH2A integrates independent functions that are instrumental in establishing a structurally and functionally unique chromatin domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 16107708 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16107708}}
==About this Structure==
==About this Structure==
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[[Category: Ncp]]
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[[Category: Nucleosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:42:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:52:42 2008''

Revision as of 07:52, 28 July 2008

Image:1u35.png

Template:STRUCTURE 1u35

Crystal structure of the nucleosome core particle containing the histone domain of macroH2A

Template:ABSTRACT PUBMED 16107708

About this Structure

1U35 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural characterization of the histone variant macroH2A., Chakravarthy S, Gundimella SK, Caron C, Perche PY, Pehrson JR, Khochbin S, Luger K, Mol Cell Biol. 2005 Sep;25(17):7616-24. PMID:16107708

Page seeded by OCA on Mon Jul 28 10:52:42 2008

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