1s7z

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{{STRUCTURE_1s7z| PDB=1s7z | SCENE= }}
{{STRUCTURE_1s7z| PDB=1s7z | SCENE= }}
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'''Structure of Ocr from Bacteriophage T7'''
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===Structure of Ocr from Bacteriophage T7===
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==Overview==
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We have solved, by X-ray crystallography to a resolution of 1.8 A, the structure of a protein capable of mimicking approximately 20 base pairs of B-form DNA. This ocr protein, encoded by gene 0.3 of bacteriophage T7, mimics the size and shape of a bent DNA molecule and the arrangement of negative charges along the phosphate backbone of B-form DNA. We also demonstrate that ocr is an efficient inhibitor in vivo of all known families of the complex type I DNA restriction enzymes. Using atomic force microscopy, we have also observed that type I enzymes induce a bend in DNA of similar magnitude to the bend in the ocr molecule. This first structure of an antirestriction protein demonstrates the construction of structural mimetics of long segments of B-form DNA.
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{{ABSTRACT_PUBMED_11804597}}
==About this Structure==
==About this Structure==
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[[Category: All helical]]
[[Category: All helical]]
[[Category: Gene regulation]]
[[Category: Gene regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:24:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:44:47 2008''

Revision as of 08:44, 28 July 2008

Image:1s7z.png

Template:STRUCTURE 1s7z

Structure of Ocr from Bacteriophage T7

Template:ABSTRACT PUBMED 11804597

About this Structure

1S7Z is a Single protein structure of sequence from Enterobacteria phage t7. Full crystallographic information is available from OCA.

Reference

Structure of Ocr from bacteriophage T7, a protein that mimics B-form DNA., Walkinshaw MD, Taylor P, Sturrock SS, Atanasiu C, Berge T, Henderson RM, Edwardson JM, Dryden DT, Mol Cell. 2002 Jan;9(1):187-94. PMID:11804597

Page seeded by OCA on Mon Jul 28 11:44:47 2008

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