1wpq

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[[Image:1wpq.gif|left|200px]]
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{{STRUCTURE_1wpq| PDB=1wpq | SCENE= }}
{{STRUCTURE_1wpq| PDB=1wpq | SCENE= }}
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'''Ternary Complex Of Glycerol 3-phosphate Dehydrogenase 1 with NAD and dihydroxyactone'''
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===Ternary Complex Of Glycerol 3-phosphate Dehydrogenase 1 with NAD and dihydroxyactone===
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==Overview==
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Homo sapiens L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1) catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate. The GPD1 protein was expressed in Escherichia coli, and purified as a fusion protein with glutathione S-transferase. Here we report the apoenzyme structure of GPD1 determined by multiwavelength anomalous diffraction phasing, and other complex structures with small molecules (NAD+ and DHAP) by the molecular replacement method. This enzyme structure is organized into two distinct domains, the N-terminal eight-stranded beta-sheet sandwich domain and the C-terminal helical substrate-binding domain. An electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of the structural analyses. In addition, the inhibitory effects of zinc and sulfate on GPDHs are assayed and discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 16460752 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16460752}}
==About this Structure==
==About this Structure==
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[[Category: Gpd1]]
[[Category: Gpd1]]
[[Category: Nad]]
[[Category: Nad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:59:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:49:14 2008''

Revision as of 08:49, 28 July 2008

Image:1wpq.png

Template:STRUCTURE 1wpq

Ternary Complex Of Glycerol 3-phosphate Dehydrogenase 1 with NAD and dihydroxyactone

Template:ABSTRACT PUBMED 16460752

About this Structure

1WPQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1)., Ou X, Ji C, Han X, Zhao X, Li X, Mao Y, Wong LL, Bartlam M, Rao Z, J Mol Biol. 2006 Mar 31;357(3):858-69. Epub 2006 Jan 18. PMID:16460752

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