2fhw

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[[Image:2fhw.gif|left|200px]]
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{{Seed}}
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[[Image:2fhw.png|left|200px]]
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{{STRUCTURE_2fhw| PDB=2fhw | SCENE= }}
{{STRUCTURE_2fhw| PDB=2fhw | SCENE= }}
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'''Solution structure of human relaxin-3'''
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===Solution structure of human relaxin-3===
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==Overview==
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Relaxin-3 is the most recently discovered member of the relaxin family of peptide hormones. In contrast to relaxin-1 and -2, whose main functions are associated with pregnancy, relaxin-3 is involved in neuropeptide signaling in the brain. Here, we report the solution structure of human relaxin-3, the first structure of a relaxin family member to be solved by NMR methods. Overall, relaxin-3 adopts an insulin-like fold, but the structure differs crucially from the crystal structure of human relaxin-2 near the B-chain terminus. In particular, the B-chain C terminus folds back, allowing Trp(B27) to interact with the hydrophobic core. This interaction partly blocks the conserved RXXXRXXI motif identified as a determinant for the interaction with the relaxin receptor LGR7 and may account for the lower affinity of relaxin-3 relative to relaxin for this receptor. This structural feature is likely important for the activation of its endogenous receptor, GPCR135.
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The line below this paragraph, {{ABSTRACT_PUBMED_16365033}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16365033 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16365033}}
==About this Structure==
==About this Structure==
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2FHW is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHW OCA].
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2FHW is a [[Protein complex]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FHW OCA].
==Reference==
==Reference==
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[[Category: Rosengren, K J.]]
[[Category: Rosengren, K J.]]
[[Category: Insulin/relaxin super-family fold]]
[[Category: Insulin/relaxin super-family fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:55:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:56:34 2008''

Revision as of 08:56, 28 July 2008

Image:2fhw.png

Template:STRUCTURE 2fhw

Solution structure of human relaxin-3

Template:ABSTRACT PUBMED 16365033

About this Structure

2FHW is a Protein complex structure. Full experimental information is available from OCA.

Reference

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3., Rosengren KJ, Lin F, Bathgate RA, Tregear GW, Daly NL, Wade JD, Craik DJ, J Biol Chem. 2006 Mar 3;281(9):5845-51. Epub 2005 Dec 19. PMID:16365033

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