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2bv6

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{{STRUCTURE_2bv6| PDB=2bv6 | SCENE= }}
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'''CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS'''
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===CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS===
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==Overview==
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Staphylococcus aureus is a human pathogen responsible for most wound and hospital-acquired infections. The protein MgrA is both an important virulence determinant during infection and a regulator of antibiotic resistance in S. aureus. The crystal structure of the MgrA homodimer, solved at 2.86 A, indicates the presence of a unique cysteine residue located at the interface of the protein dimer. We discovered that this cysteine residue can be oxidized by various reactive oxygen species, such as hydrogen peroxide and organic hydroperoxide. Cysteine oxidation leads to dissociation of MgrA from DNA and initiation of signaling pathways that turn on antibiotic resistance in S. aureus. The oxidation-sensing mechanism is typically used by bacteria to counter challenges of reactive oxygen and nitrogen species. Our study reveals that in S. aureus, MgrA adopts a similar mechanism but uses it to globally regulate different defensive pathways.
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{{ABSTRACT_PUBMED_16980961}}
==About this Structure==
==About this Structure==
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[[Category: Transcriptional factor]]
[[Category: Transcriptional factor]]
[[Category: Virulence determinant]]
[[Category: Virulence determinant]]
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Revision as of 09:18, 28 July 2008

Image:2bv6.png

Template:STRUCTURE 2bv6

CRYSTAL STRUCTURE OF MGRA, A GLOBAL REGULATOR AND MAJOR VIRULENCE DETERMINANT IN STAPHYLOCOCCUS AUREUS

Template:ABSTRACT PUBMED 16980961

About this Structure

2BV6 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus., Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C, Nat Chem Biol. 2006 Nov;2(11):591-5. Epub 2006 Sep 17. PMID:16980961

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