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1trb

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[[Image:1trb.gif|left|200px]]
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{{STRUCTURE_1trb| PDB=1trb | SCENE= }}
{{STRUCTURE_1trb| PDB=1trb | SCENE= }}
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'''CONVERGENT EVOLUTION OF SIMILAR FUNCTION IN TWO STRUCTURALLY DIVERGENT ENZYMES'''
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===CONVERGENT EVOLUTION OF SIMILAR FUNCTION IN TWO STRUCTURALLY DIVERGENT ENZYMES===
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==Overview==
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An example of two related enzymes that catalyse similar reactions but possess different active sites is provided by comparing the structure of Escherichia coli thioredoxin reductase with glutathione reductase. Both are dimeric enzymes that catalyse the reduction of disulphides by pyridine nucleotides through an enzyme disulphide and a flavin. Human glutathione reductase contains four structural domains within each molecule: the flavin-adenine dinucleotide (FAD)- and nicotinamide-adenine dinucleotide phosphate (NADPH)-binding domains, the 'central' domain and the C-terminal domain that provides the dimer interface and part of the active site. Although both enzymes share the same catalytic mechanism and similar tertiary structures, their active sites do not resemble each other. We have determined the crystal structure of E. coli thioredoxin reductase at 2 A resolution, and show that thioredoxin reductase lacks the domain that provides the dimer interface in glutathione reductase, and forms a completely different dimeric structure. The catalytically active disulphides are located in different domains on opposite sides of the flavin ring system. This suggests that these enzymes diverged from an ancestral nucleotide-binding protein and acquired their disulphide reductase activities independently.
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(as it appears on PubMed at http://www.pubmed.gov), where 2067578 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2067578}}
==About this Structure==
==About this Structure==
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[[Category: Krishna, T S.R.]]
[[Category: Krishna, T S.R.]]
[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:17:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:20:15 2008''

Revision as of 09:20, 28 July 2008

Image:1trb.png

Template:STRUCTURE 1trb

CONVERGENT EVOLUTION OF SIMILAR FUNCTION IN TWO STRUCTURALLY DIVERGENT ENZYMES

Template:ABSTRACT PUBMED 2067578

About this Structure

1TRB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Convergent evolution of similar function in two structurally divergent enzymes., Kuriyan J, Krishna TS, Wong L, Guenther B, Pahler A, Williams CH Jr, Model P, Nature. 1991 Jul 11;352(6331):172-4. PMID:2067578

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