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1xc5

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[[Image:1xc5.gif|left|200px]]
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{{STRUCTURE_1xc5| PDB=1xc5 | SCENE= }}
{{STRUCTURE_1xc5| PDB=1xc5 | SCENE= }}
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'''Solution Structure of the SMRT Deacetylase Activation Domain'''
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===Solution Structure of the SMRT Deacetylase Activation Domain===
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==Overview==
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SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) and NCoR (nuclear receptor corepressor) are transcriptional corepressors that play an essential role in the regulation of development and metabolism. This role is achieved, in part, through the recruitment of a key histone deacetylase (HDAC3), which is itself indispensable for cell viability. The assembly of HDAC3 with the deacetylase activation domain (DAD) of SMRT and NCoR is required for activation of the otherwise inert deacetylase. The DAD comprises an N-terminal DAD-specific motif and a C-terminal SANT (SWI3/ADA2/NCoR/TFIIIB)-like domain. We report here the solution structure of the DAD from SMRT, which reveals a four-helical structure. The DAD differs from the SANT (and MYB) domains in that (i) it has an additional N-terminal helix and (ii) there is a notable hydrophobic groove on the surface of the domain. Structure-guided mutagenesis, combined with interaction assays, showed that residues in the vicinity of the hydrophobic groove are required for interaction with (and hence activation of) HDAC3. Importantly, one surface-exposed lysine is required for activation of HDAC3, but not for interaction. This lysine may play a uniquely important role in the mechanism of activating HDAC3.
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(as it appears on PubMed at http://www.pubmed.gov), where 15837933 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837933}}
==About this Structure==
==About this Structure==
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1XC5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XC5 OCA].
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1XC5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XC5 OCA].
==Reference==
==Reference==
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[[Category: Four-helix structure]]
[[Category: Four-helix structure]]
[[Category: Three-helix triangle]]
[[Category: Three-helix triangle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:38:18 2008''

Revision as of 09:38, 28 July 2008

Image:1xc5.png

Template:STRUCTURE 1xc5

Solution Structure of the SMRT Deacetylase Activation Domain

Template:ABSTRACT PUBMED 15837933

About this Structure

1XC5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors., Codina A, Love JD, Li Y, Lazar MA, Neuhaus D, Schwabe JW, Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6009-14. Epub 2005 Apr 18. PMID:15837933

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