1vaz

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[[Image:1vaz.gif|left|200px]]
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{{STRUCTURE_1vaz| PDB=1vaz | SCENE= }}
{{STRUCTURE_1vaz| PDB=1vaz | SCENE= }}
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'''Solution structures of the p47 SEP domain'''
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===Solution structures of the p47 SEP domain===
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==Overview==
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p47 is a major adaptor molecule of the cytosolic AAA ATPase p97. The principal role of the p97-p47 complex is in regulation of membrane fusion events. Mono-ubiquitin recognition by p47 has also been shown to be crucial in the p97-p47-mediated Golgi membrane fusion events. Here, we describe the high-resolution solution structures of the N-terminal UBA domain and the central domain (SEP) from p47. The p47 UBA domain has the characteristic three-helix bundle fold and forms a highly stable complex with ubiquitin. We report the interaction surfaces of the two proteins and present a structure for the p47 UBA-ubiquitin complex. The p47 SEP domain adopts a novel fold with a betabetabetaalphaalphabeta secondary structure arrangement, where beta4 pairs in a parallel fashion to beta1. Based on biophysical studies, we demonstrate a clear propensity for the self-association of p47. Furthermore, p97 N binding abolishes p47 self-association, revealing the potential interaction surfaces for recognition of other domains within p97 or the substrate.
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{{ABSTRACT_PUBMED_15029246}}
==About this Structure==
==About this Structure==
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1VAZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VAZ OCA].
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1VAZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VAZ OCA].
==Reference==
==Reference==
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[[Category: Beta-beta-beta-alpha-alpha-beta]]
[[Category: Beta-beta-beta-alpha-alpha-beta]]
[[Category: Novel fold]]
[[Category: Novel fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:19:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:40:50 2008''

Revision as of 09:40, 28 July 2008

Image:1vaz.png

Template:STRUCTURE 1vaz

Solution structures of the p47 SEP domain

Template:ABSTRACT PUBMED 15029246

About this Structure

1VAZ is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97., Yuan X, Simpson P, McKeown C, Kondo H, Uchiyama K, Wallis R, Dreveny I, Keetch C, Zhang X, Robinson C, Freemont P, Matthews S, EMBO J. 2004 Apr 7;23(7):1463-73. Epub 2004 Mar 18. PMID:15029246

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