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1r3h

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{{STRUCTURE_1r3h| PDB=1r3h | SCENE= }}
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'''Crystal Structure of T10'''
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===Crystal Structure of T10===
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==Overview==
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T10 is a non-classical class Ib-like major histocompatibility complex (MHC) cell-surface antigen which binds directly to certain gammadelta T-cell receptors in the absence of any exogenous and endogenous ligands, such as peculiar lipids or glycolipids. The crystal structure at 2.5 A resolution of murine T10 was determined by molecular replacement using data from an almost perfectly twinned monoclinic crystal. The space group is P2(1), with unit-cell parameters a = 78.2, b = 70.0, c = 139.2 A, beta = 106.8 degrees. Self-rotation function analysis and various intensity statistics revealed the presence of pseudo-merohedral twinning, but these tests underestimated the true twin fraction of alpha approximately 0.46. Native Patterson analyses pointed to the presence of pseudo-translation among the four molecules present in the asymmetric unit. Data analysis, structure determination and model refinement are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15039553 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15039553}}
==Disease==
==Disease==
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[[Category: Class ib mhc]]
[[Category: Class ib mhc]]
[[Category: Gammadelta t cell ligand]]
[[Category: Gammadelta t cell ligand]]
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Revision as of 09:52, 28 July 2008

Image:1r3h.png

Template:STRUCTURE 1r3h

Contents

Crystal Structure of T10

Template:ABSTRACT PUBMED 15039553

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1R3H is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10., Rudolph MG, Wingren C, Crowley MP, Chien YH, Wilson IA, Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):656-64. Epub 2004, Mar 23. PMID:15039553

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