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1u8y

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{{STRUCTURE_1u8y| PDB=1u8y | SCENE= }}
{{STRUCTURE_1u8y| PDB=1u8y | SCENE= }}
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'''CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap'''
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===CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap===
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==Overview==
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RalA is a GTPase with effectors such as Sec5 and Exo84 in the exocyst complex and RalBP1, a GAP for Rho proteins. We report the crystal structures of Ral-GppNHp and Ral-GDP. Disordered switch I and switch II, located away from crystal contacts, are observed in one of the molecules in the asymmetric unit of the Ral-GppNHp structure. In the other molecule in the asymmetric unit, a second Mg(2+) ion is bound to the GppNHp gamma-phosphate in an environment in which switch I is pulled away from the nucleotide and switch II is found in a tight beta turn. Clustering of conserved residues on the surface of Ral-GppNHp identifies two putative sites for protein-protein interaction. One site is adjacent to switch I. The other is modulated by switch II and is obstructed in Ral-GDP. The Ral structures are discussed in the context of the published structures of the Ral/Sec5 complex, Ras, and Rap.
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(as it appears on PubMed at http://www.pubmed.gov), where 15530367 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15530367}}
==About this Structure==
==About this Structure==
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[[Category: Serrano, V de.]]
[[Category: Serrano, V de.]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:54:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:08:33 2008''

Revision as of 10:08, 28 July 2008

Image:1u8y.png

Template:STRUCTURE 1u8y

CRystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap

Template:ABSTRACT PUBMED 15530367

About this Structure

1U8Y is a Single protein structure of sequence from Saguinus oedipus. Full crystallographic information is available from OCA.

Reference

Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap., Nicely NI, Kosak J, de Serrano V, Mattos C, Structure. 2004 Nov;12(11):2025-36. PMID:15530367

Page seeded by OCA on Mon Jul 28 13:08:33 2008

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