1omk

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{{STRUCTURE_1omk| PDB=1omk | SCENE= }}
{{STRUCTURE_1omk| PDB=1omk | SCENE= }}
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'''The Crystal Structure of d(CACG(5IU)G)'''
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===The Crystal Structure of d(CACG(5IU)G)===
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==Overview==
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The first antiviral nucleoside 5-iodo-2'-deoxyuridine (IDU) against herpes simplex virus type 1 and type 2 is a thymidine analogue, i.e. the C5 methyl group is replaced by an I atom. The structure of the self-complementary hexamer d[CACG(IDU)G] was determined by single-crystal X-ray diffraction techniques. The orthorhombic crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 18.16, b = 30.03, c = 41.99 A. Refinement in the resolution range 20-1.3 A converged with a final R1 = 0.167, including 43 water molecules and two cobalt hexammine complexes. The incorporation of a large I atom has only minor consequences for the overall structure as is noticed in the IDU.A base pairs, which are of the common Watson-Crick type. To contribute to the still puzzling mechanism of this historically important agent, details of base stacking, helical parameters, hydration etc. have been studied. A general scheme of cobalt hexammine-binding modes in Z-DNA is provided, revealing similar binding modes for the reported structure.
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(as it appears on PubMed at http://www.pubmed.gov), where 12876373 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12876373}}
==About this Structure==
==About this Structure==
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[[Category: 5-iodo-2'-deoxyuridine]]
[[Category: 5-iodo-2'-deoxyuridine]]
[[Category: Z-dna]]
[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:02:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:38:29 2008''

Revision as of 10:38, 28 July 2008

Image:1omk.png

Template:STRUCTURE 1omk

The Crystal Structure of d(CACG(5IU)G)

Template:ABSTRACT PUBMED 12876373

About this Structure

Full crystallographic information is available from OCA.

Reference

Exploration of the influence of 5-iodo-2'-deoxyuridine incorporation on the structure of d[CACG(IDU)G]., Schuerman G, Van Hecke K, Van Meervelt L, Acta Crystallogr D Biol Crystallogr. 2003 Aug;59(Pt 8):1525-8. Epub 2003, Jul 23. PMID:12876373

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