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1usp

From Proteopedia

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{{STRUCTURE_1usp| PDB=1usp | SCENE= }}
{{STRUCTURE_1usp| PDB=1usp | SCENE= }}
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'''ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN FROM DEINOCOCCUS RADIODURANS'''
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===ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN FROM DEINOCOCCUS RADIODURANS===
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==Overview==
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The three-dimensional structure of the organic hydroperoxide resistance protein (OHRP) from Deinococcus radiodurans as determined using single crystal xray diffraction techniques is reported. Comparison of the structure with that obtained for OHRP from Pseudomonas aeruginosa reveals that the polypeptide chain of OHRPs can adopt two significantly different conformations ("in" and "out") in the region of the active site disulfide moiety. It is postulated that the closed configuration is consistent with efficient catalysis of the reduction of organic hydroperoxides, whereas the open form is required for enzyme recycling. Comparison of the structures of OHRP and that of the osmotically induced protein C (OsmC) from Mycoplasma pneumoniae shows that OHRPs and OsmCs are structurally homologous, perhaps indicating related functions for the two families of proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15054099}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15054099 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15054099}}
==About this Structure==
==About this Structure==
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[[Category: Meunier-Jamin, C.]]
[[Category: Meunier-Jamin, C.]]
[[Category: 2-cys peroxidase]]
[[Category: 2-cys peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:38:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:39:12 2008''

Revision as of 10:39, 28 July 2008

Image:1usp.png

Template:STRUCTURE 1usp

ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN FROM DEINOCOCCUS RADIODURANS

Template:ABSTRACT PUBMED 15054099

About this Structure

1USP is a Protein complex structure of sequences from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

The structure of the organic hydroperoxide resistance protein from Deinococcus radiodurans. Do conformational changes facilitate recycling of the redox disulfide?, Meunier-Jamin C, Kapp U, Leonard GA, McSweeney S, J Biol Chem. 2004 Jun 11;279(24):25830-7. Epub 2004 Mar 30. PMID:15054099

Page seeded by OCA on Mon Jul 28 13:39:12 2008

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