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1zxm

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[[Image:1zxm.gif|left|200px]]
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{{Seed}}
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[[Image:1zxm.png|left|200px]]
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{{STRUCTURE_1zxm| PDB=1zxm | SCENE= }}
{{STRUCTURE_1zxm| PDB=1zxm | SCENE= }}
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'''Human Topo IIa ATPase/AMP-PNP'''
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===Human Topo IIa ATPase/AMP-PNP===
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==Overview==
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Type IIA DNA topoisomerases play multiple essential roles in the management of higher-order DNA structure, including modulation of topological state, chromosome segregation, and chromatin condensation. These diverse physiologic functions are all accomplished through a common molecular mechanism, wherein the protein catalyzes transient cleavage of a DNA duplex (the G-segment) to yield a double-stranded gap through which another duplex (the T-segment) is passed. The overall process is orchestrated by the opening and closing of molecular "gates" in the topoisomerase structure, which is regulated by ATP binding, hydrolysis, and release of ADP and inorganic phosphate. Here we present two crystal structures of the ATPase domain of human DNA topoisomerase IIalpha in different nucleotide-bound states. Comparison of these structures revealed rigid-body movement of the structural modules within the ATPase domain, suggestive of the motions of a molecular gate.
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The line below this paragraph, {{ABSTRACT_PUBMED_16100112}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16100112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16100112}}
==About this Structure==
==About this Structure==
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[[Category: Wei, H.]]
[[Category: Wei, H.]]
[[Category: Ghkl nucleotide-binding fold]]
[[Category: Ghkl nucleotide-binding fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:12:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:51:41 2008''

Revision as of 10:51, 28 July 2008

Image:1zxm.png

Template:STRUCTURE 1zxm

Human Topo IIa ATPase/AMP-PNP

Template:ABSTRACT PUBMED 16100112

About this Structure

1ZXM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase., Wei H, Ruthenburg AJ, Bechis SK, Verdine GL, J Biol Chem. 2005 Nov 4;280(44):37041-7. Epub 2005 Aug 12. PMID:16100112

Page seeded by OCA on Mon Jul 28 13:51:41 2008

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