This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2zcy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2zcy.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2zcy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2zcy| PDB=2zcy | SCENE= }}
{{STRUCTURE_2zcy| PDB=2zcy | SCENE= }}
-
'''yeast 20S proteasome:syringolin A-complex'''
+
===yeast 20S proteasome:syringolin A-complex===
-
==Overview==
+
<!--
-
Pathogenic bacteria often use effector molecules to increase virulence. In most cases, the mode of action of effectors remains unknown. Strains of Pseudomonas syringae pv. syringae (Pss) secrete syringolin A (SylA), a product of a mixed non-ribosomal peptide/polyketide synthetase, in planta. Here we identify SylA as a virulence factor because a SylA-negative mutant in Pss strain B728a obtained by gene disruption was markedly less virulent on its host, Phaseolus vulgaris (bean). We show that SylA irreversibly inhibits all three catalytic activities of eukaryotic proteasomes, thus adding proteasome inhibition to the repertoire of modes of action of virulence factors. The crystal structure of the yeast proteasome in complex with SylA revealed a novel mechanism of covalent binding to the catalytic subunits. Thus, SylA defines a new class of proteasome inhibitors that includes glidobactin A (GlbA), a structurally related compound from an unknown species of the order Burkholderiales, for which we demonstrate a similar proteasome inhibition mechanism. As proteasome inhibitors are a promising class of anti-tumour agents, the discovery of a novel family of inhibitory natural products, which we refer to as syrbactins, may also have implications for the development of anti-cancer drugs. Homologues of SylA and GlbA synthetase genes are found in some other pathogenic bacteria, including the human pathogen Burkholderia pseudomallei, the causative agent of melioidosis. It is thus possible that these bacteria are capable of producing proteasome inhibitors of the syrbactin class.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18401409}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18401409 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18401409}}
==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation]]
[[Category: Zymogen]]
[[Category: Zymogen]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:09:36 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:05:04 2008''

Revision as of 11:05, 28 July 2008

Image:2zcy.png

Template:STRUCTURE 2zcy

yeast 20S proteasome:syringolin A-complex

Template:ABSTRACT PUBMED 18401409

About this Structure

2ZCY is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism., Groll M, Schellenberg B, Bachmann AS, Archer CR, Huber R, Powell TK, Lindow S, Kaiser M, Dudler R, Nature. 2008 Apr 10;452(7188):755-8. PMID:18401409

Page seeded by OCA on Mon Jul 28 14:05:04 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zcy"
Personal tools