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1wqg

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[[Image:1wqg.gif|left|200px]]
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{{STRUCTURE_1wqg| PDB=1wqg | SCENE= }}
{{STRUCTURE_1wqg| PDB=1wqg | SCENE= }}
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'''Crystal structure of ribosome recycling factor from Mycobacterium Tuberculosis'''
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===Crystal structure of ribosome recycling factor from Mycobacterium Tuberculosis===
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==Overview==
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The crystal structure of Mycobacterium tuberculosis ribosome recycling factor has been determined and refined against three X-ray diffraction data sets, two collected at room temperature and the other at 100K. The two room-temperature data sets differ in the radiation damage suffered by the crystals before the data used for processing were collected. A comparison between the structures refined against the two data sets indicates the possibility of radiation-induced conformational change. The L-shaped molecule is composed of a long three-helix bundle domain (domain I) and a globular domain (domain II) connected by a linker region. The main difference between the room-temperature structure and the low temperature structure is in the rotation of domain II about an axis close to its libration axis. This observation and a detailed comparative study of ribosome recycling factors (RRFs) of known structures led to an elaboration of the present understanding of the structural variability of RRF. The variability involves a change in the angle between the two arms of the molecule, a rotation of domain II in a plane nearly perpendicular to the axis of the helix bundle and an internal rotation of domain II. Furthermore, the domains and the linker could be delineated into fixed and variable regions in a physically meaningful manner. The relative mobility of the domains of the molecule in the crystal structure appears to be similar to that in the ribosome--RRF complex. That permits a meaningful discussion of the structural features of RRF in terms of ribosome--RRF interactions. The structure also provides insights into the results of inter-species complementation studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 15567408 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15567408}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
X-ray structural studies of Mycobacterium tuberculosis RRF and a comparative study of RRFs of known structure. Molecular plasticity and biological implications., Saikrishnan K, Kalapala SK, Varshney U, Vijayan M, J Mol Biol. 2005 Jan 7;345(1):29-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15567408 15567408]
X-ray structural studies of Mycobacterium tuberculosis RRF and a comparative study of RRFs of known structure. Molecular plasticity and biological implications., Saikrishnan K, Kalapala SK, Varshney U, Vijayan M, J Mol Biol. 2005 Jan 7;345(1):29-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15567408 15567408]
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Purification, crystallization and preliminary X-ray studies of Mycobacterium tuberculosis RRF., Saikrishnan K, Kalapala SK, Bidya Sagar M, Rao AR, Varshney U, Vijayan M, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):368-70. Epub 2004, Jan 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14747728 14747728]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Translation factor]]
[[Category: Translation factor]]
[[Category: Triple-helix bundle]]
[[Category: Triple-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:00:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:06:16 2008''

Revision as of 11:06, 28 July 2008

Image:1wqg.png

Template:STRUCTURE 1wqg

Crystal structure of ribosome recycling factor from Mycobacterium Tuberculosis

Template:ABSTRACT PUBMED 15567408

About this Structure

1WQG is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

X-ray structural studies of Mycobacterium tuberculosis RRF and a comparative study of RRFs of known structure. Molecular plasticity and biological implications., Saikrishnan K, Kalapala SK, Varshney U, Vijayan M, J Mol Biol. 2005 Jan 7;345(1):29-38. PMID:15567408

Purification, crystallization and preliminary X-ray studies of Mycobacterium tuberculosis RRF., Saikrishnan K, Kalapala SK, Bidya Sagar M, Rao AR, Varshney U, Vijayan M, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):368-70. Epub 2004, Jan 23. PMID:14747728

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