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1rji

From Proteopedia

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[[Image:1rji.gif|left|200px]]
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{{STRUCTURE_1rji| PDB=1rji | SCENE= }}
{{STRUCTURE_1rji| PDB=1rji | SCENE= }}
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'''Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch'''
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===Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch===
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==Overview==
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Scorpion venom is a rich source of bioactive peptides. From the venom of Chinese scorpion Buthus martensi Karsch (BmK), a novel short chain peptide BmKX of 31-amino acid residues was purified, and its amino acid sequence and gene structure were determined. The gene of BmKX was composed of two exons interrupted by an 86-bp intron at the codon-7 upstream of the mature peptide. Although its gene structure is similar to those of other known scorpion toxins, its amino acid sequence, especially the cysteine framework, is different from those of all other known subfamilies of short-chain scorpion toxins. The solution structure of BmKX, determined with two-dimensional NMR spectroscopy, shows that BmKX also forms a typical cysteine-stabilized alpha/beta scaffold adopted by most short-chain scorpion toxins, consisting of a short 3(10)-helix and a two-stranded antiparallel beta-sheet, and the short N-terminal segment forms a pseudo-strand of the beta-sheet. However, the orientation between the helix and the beta-sheet is significantly different from the others, which might be the reason for its unique but still unclear physiological function.
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(as it appears on PubMed at http://www.pubmed.gov), where 15683869 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15683869}}
==About this Structure==
==About this Structure==
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1RJI is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJI OCA].
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1RJI is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJI OCA].
==Reference==
==Reference==
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[[Category: 3-10 helix]]
[[Category: 3-10 helix]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:34:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:23:53 2008''

Revision as of 11:23, 28 July 2008

Image:1rji.png

Template:STRUCTURE 1rji

Solution Structure of BmKX, a novel potassium channel blocker from the Chinese Scorpion Buthus martensi Karsch

Template:ABSTRACT PUBMED 15683869

About this Structure

1RJI is a Single protein structure. Full experimental information is available from OCA.

Reference

A novel short-chain peptide BmKX from the Chinese scorpion Buthus martensi Karsch, sequencing, gene cloning and structure determination., Wang CG, Cai Z, Lu W, Wu J, Xu Y, Shi Y, Chi CW, Toxicon. 2005 Mar 1;45(3):309-19. Epub 2005 Jan 20. PMID:15683869

Page seeded by OCA on Mon Jul 28 14:23:53 2008

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