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2dn2

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{{STRUCTURE_2dn2| PDB=2dn2 | SCENE= }}
{{STRUCTURE_2dn2| PDB=2dn2 | SCENE= }}
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'''1.25A resolution crystal structure of human hemoglobin in the deoxy form'''
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===1.25A resolution crystal structure of human hemoglobin in the deoxy form===
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==Overview==
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The most recent refinement of the crystallographic structure of oxyhaemoglobin (oxyHb) was completed in 1983, and differences between this real-space refined model and later R state models have been interpreted as evidence of crystallisation artefacts, or numerous sub-states. We have refined models of deoxy, oxy and carbonmonoxy Hb to 1.25 A resolution each, and compare them with other Hb structures. It is shown that the older structures reflect the software used in refinement, and many differences with newer structures are unlikely to be physiologically relevant. The improved accuracy of our models clarifies the disagreement between NMR and X-ray studies of oxyHb, the NMR experiments suggesting a hydrogen bond to exist between the distal histidine and oxygen ligand of both the alpha and beta-subunits. The high-resolution crystal structure also reveals a hydrogen bond in both subunit types, but with subtly different geometry which may explain the very different behaviour when this residue is mutated to glycine in alpha or beta globin. We also propose a new set of relatively fixed residues to act as a frame of reference; this set contains a similar number of atoms to the well-known "BGH" frame yet shows a much smaller rmsd value between R and T state models of HbA.
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(as it appears on PubMed at http://www.pubmed.gov), where 16765986 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16765986}}
==About this Structure==
==About this Structure==
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[[Category: Human hemoglobin]]
[[Category: Human hemoglobin]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:47:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:33:56 2008''

Revision as of 11:34, 28 July 2008

Image:2dn2.png

Template:STRUCTURE 2dn2

1.25A resolution crystal structure of human hemoglobin in the deoxy form

Template:ABSTRACT PUBMED 16765986

About this Structure

2DN2 is a Protein complex structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 2dfq. Full crystallographic information is available from OCA.

Reference

1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms., Park SY, Yokoyama T, Shibayama N, Shiro Y, Tame JR, J Mol Biol. 2006 Jul 14;360(3):690-701. Epub 2006 May 30. PMID:16765986

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