2f8x

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[[Image:2f8x.gif|left|200px]]
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{{STRUCTURE_2f8x| PDB=2f8x | SCENE= }}
{{STRUCTURE_2f8x| PDB=2f8x | SCENE= }}
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'''Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence'''
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===Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence===
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==Overview==
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Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16530044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16530044}}
==About this Structure==
==About this Structure==
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[[Category: Notch]]
[[Category: Notch]]
[[Category: Rel-homology region]]
[[Category: Rel-homology region]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:36:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:35:04 2008''

Revision as of 11:35, 28 July 2008

Image:2f8x.png

Template:STRUCTURE 2f8x

Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence

Template:ABSTRACT PUBMED 16530044

About this Structure

2F8X is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes., Nam Y, Sliz P, Song L, Aster JC, Blacklow SC, Cell. 2006 Mar 10;124(5):973-83. PMID:16530044

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