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1yrx

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{{STRUCTURE_1yrx| PDB=1yrx | SCENE= }}
{{STRUCTURE_1yrx| PDB=1yrx | SCENE= }}
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'''Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides'''
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===Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides===
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==Overview==
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The flavin-binding BLUF domain of AppA represents a new class of blue light photoreceptors that are present in a number of bacterial and algal species. The dark state X-ray structure of this domain was determined at 2.3 A resolution. The domain demonstrates a new function for the common ferredoxin-like fold; two long alpha-helices flank the flavin, which is bound with its isoalloxazine ring perpendicular to a five-stranded beta-sheet. The hydrogen bond network and the overall protein topology of the BLUF domain (but not its sequence) bear some resemblance to LOV domains, a subset of PAS domains widely involved in signaling. Nearly all residues conserved in BLUF domains surround the flavin chromophore, many of which are involved in an intricate hydrogen bond network. Photoactivation may induce a rearrangement in this network via reorientation of the Gln63 side chain to form a new hydrogen bond to the flavin O4 position. This shift would also break a hydrogen bond to the Trp104 side chain, which may be critical in induction of global structural change in AppA.
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(as it appears on PubMed at http://www.pubmed.gov), where 15924418 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15924418}}
==About this Structure==
==About this Structure==
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[[Category: Flavin binding]]
[[Category: Flavin binding]]
[[Category: Photoreceptor]]
[[Category: Photoreceptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:42:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:38:31 2008''

Revision as of 11:38, 28 July 2008

Image:1yrx.png

Template:STRUCTURE 1yrx

Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides

Template:ABSTRACT PUBMED 15924418

About this Structure

1YRX is a Single protein structure of sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

Structure of a novel photoreceptor, the BLUF domain of AppA from Rhodobacter sphaeroides., Anderson S, Dragnea V, Masuda S, Ybe J, Moffat K, Bauer C, Biochemistry. 2005 Jun 7;44(22):7998-8005. PMID:15924418

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