1svr

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[[Image:1svr.gif|left|200px]]
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{{STRUCTURE_1svr| PDB=1svr | SCENE= }}
{{STRUCTURE_1svr| PDB=1svr | SCENE= }}
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'''STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION'''
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===STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION===
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==Overview==
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The three-dimensional structure of domain 2 of severin in aqueous solution was determined by nuclear magnetic resonance spectroscopy. Severin is a Ca(2+)-activated actin-binding protein that servers F-actin, nucleates actin assembly, and caps the fast-growing ends of actin filaments. The 114-residue domain consists of a central five-stranded beta-sheet, sandwiched between a parallel four-turn alpha-helix and, on the other face, a roughly perpendicular two-turn alpha-helix. There are two distinct binding sites for Ca2+ located near the N and C termini of the long helix. Conserved residues of the gelsolin-severin family contribute to the apolar core of domain 2 of severin, so that the overall fold of the protein is similar to those of segment 1 of gelsolin and profilins. Together with biochemical experiments, this structure helps to explain how severin interacts with actin.
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{{ABSTRACT_PUBMED_7897658}}
==About this Structure==
==About this Structure==
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1SVR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVR OCA].
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1SVR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVR OCA].
==Reference==
==Reference==
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[[Category: Schnuchel, A.]]
[[Category: Schnuchel, A.]]
[[Category: Actin-binding]]
[[Category: Actin-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:45:17 2008''

Revision as of 11:45, 28 July 2008

Image:1svr.png

Template:STRUCTURE 1svr

STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION

Template:ABSTRACT PUBMED 7897658

About this Structure

1SVR is a Single protein structure of sequence from Dictyostelium discoideum. Full experimental information is available from OCA.

Reference

Structure of severin domain 2 in solution., Schnuchel A, Wiltscheck R, Eichinger L, Schleicher M, Holak TA, J Mol Biol. 1995 Mar 17;247(1):21-7. PMID:7897658

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