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2csb

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[[Image:2csb.gif|left|200px]]
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{{Seed}}
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[[Image:2csb.png|left|200px]]
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{{STRUCTURE_2csb| PDB=2csb | SCENE= }}
{{STRUCTURE_2csb| PDB=2csb | SCENE= }}
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'''Crystal structure of Topoisomerase V from Methanopyrus kandleri (61 kDa fragment)'''
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===Crystal structure of Topoisomerase V from Methanopyrus kandleri (61 kDa fragment)===
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==Overview==
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Topoisomerases are involved in controlling and maintaining the topology of DNA and are present in all kingdoms of life. Unlike all other types of topoisomerases, similar type IB enzymes have only been identified in bacteria and eukarya. The only putative type IB topoisomerase in archaea is represented by Methanopyrus kandleri topoisomerase V. Despite several common functional characteristics, topoisomerase V shows no sequence similarity to other members of the same type. The structure of the 61 kDa N-terminal fragment of topoisomerase V reveals no structural similarity to other topoisomerases. Furthermore, the structure of the active site region is different, suggesting no conservation in the cleavage and religation mechanism. Additionally, the active site is buried, indicating the need of a conformational change for activity. The presence of a topoisomerase in archaea with a unique structure suggests the evolution of a separate mechanism to alter DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_16395333}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16395333 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16395333}}
==About this Structure==
==About this Structure==
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[[Category: Topoisomerase ib]]
[[Category: Topoisomerase ib]]
[[Category: Topoisomerase v]]
[[Category: Topoisomerase v]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:56:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:47:16 2008''

Revision as of 11:47, 28 July 2008

Image:2csb.png

Template:STRUCTURE 2csb

Crystal structure of Topoisomerase V from Methanopyrus kandleri (61 kDa fragment)

Template:ABSTRACT PUBMED 16395333

About this Structure

2CSB is a Single protein structure of sequence from Methanopyrus kandleri. Full crystallographic information is available from OCA.

Reference

Structure of the N-terminal fragment of topoisomerase V reveals a new family of topoisomerases., Taneja B, Patel A, Slesarev A, Mondragon A, EMBO J. 2006 Jan 25;25(2):398-408. Epub 2006 Jan 5. PMID:16395333

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