1zv6

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[[Image:1zv6.gif|left|200px]]
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{{Seed}}
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[[Image:1zv6.png|left|200px]]
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{{STRUCTURE_1zv6| PDB=1zv6 | SCENE= }}
{{STRUCTURE_1zv6| PDB=1zv6 | SCENE= }}
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'''NMR structure of the human dematin headpiece S74E mutant'''
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===NMR structure of the human dematin headpiece S74E mutant===
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==Overview==
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Dematin is an actin binding protein from the junctional complex of the erythrocyte cytoskeleton. The protein has two actin binding sites and bundles actin filaments in vitro. This actin bundling activity is reversibly regulated by phosphorylation in the carboxyl terminal "headpiece" domain (DHP). DHP is a typical villin-type headpiece actin binding motif and contains a flexible N-terminal loop and an alpha-helical C-terminal subdomain that is phosphorylated at Ser74. The NMR structure of a Ser74-to-Glu mutant (DHPs74e) closely mimics the conformation of phosphorylated DHP. The negative charge at Ser74 does not alter the conformation of the C-terminal subdomain, but attracts the N-terminal loop toward the C terminus, changing the orientation of the N-terminal subdomain. NMR relaxation studies also indicate reduced mobility in the N-terminal loop in DHPs74e. Thus, phosphorylation in DHP serves as a switch controlling the conformational state of DHP and the actin bundling activity of dematin.
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The line below this paragraph, {{ABSTRACT_PUBMED_16472756}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16472756 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16472756}}
==About this Structure==
==About this Structure==
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1ZV6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV6 OCA].
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1ZV6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV6 OCA].
==Reference==
==Reference==
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[[Category: Dematin headpiece]]
[[Category: Dematin headpiece]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:06:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:13:48 2008''

Revision as of 12:13, 28 July 2008

Image:1zv6.png

Template:STRUCTURE 1zv6

NMR structure of the human dematin headpiece S74E mutant

Template:ABSTRACT PUBMED 16472756

About this Structure

1ZV6 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

A phosphorylation-induced conformation change in dematin headpiece., Jiang ZG, McKnight CJ, Structure. 2006 Feb;14(2):379-87. PMID:16472756

Page seeded by OCA on Mon Jul 28 15:13:48 2008

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